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Green Light Labile BODIPY Protecting Groups for Glycan Synthesis

S. Leichnitz, K. C. Dissanayake, A. H. Winter, P. H. Seeberger – 2022

Protective groups that can be selectively removed under mild conditions are an essential aspect of carbohydrate chemistry. Groups that can be selectively removed by visible light are particularly attractive because carbohydrates are transparent to visible light. Here, different BODIPY protecting groups were explored for their utility during glycan synthesis. A BODIPY group bearing a boron difluoride unit is stable during glycosylations but can be cleaved with green light as illustrated by the assembly of a trisaccharide.

Title
Green Light Labile BODIPY Protecting Groups for Glycan Synthesis
Author
S. Leichnitz, K. C. Dissanayake, A. H. Winter, P. H. Seeberger
Date
2022
Identifier
10.1039/D2CC03851J
Source(s)
Citation
Chem. Commun., 2022, 58, 10556-10559
Type
Text