2:00 – 3:00 pm
Prof. Wolf-Dietrich Hardt (ETH)
"Breaching the barrier: The Salmonella diarrhea case"
The intestinal mucosa is protected by chemical barriers, by the microbiota and by a thick mucus layer. Nevertheless, some pathogens have evolved strategies to breach these barriers in order to attack the gut epithelium and cause disease. We are studying the enteropathogenic bacterium Salmonella Typhimurium, using mouse infection models to learn about the pathogen's virulence strategies, its evolution into an enteropathogenic bacterium, and to identify the relevant mucosal defenses. In my talk, I will discuss the protective function of the mucus layer, its architecture and voids. S. Typhimurium employs flagella-driven motility in order to capitalize on these voids for crossing the mucus layer, to reach the gut epithelium and to invade into the gut tissue. The invasion elicits an inflammasome-driven innate immune response which reduces the pathogen loads in the gut tissue, alters the mucus architecture and modifies the gut-luminal milieu, with dramatic effects on the pathogen's gut luminal growth. The pathogen-elicited luminal blooms explain the pathogenic lifestyle of Salmonella Typhimurium.
Time & Location
Jun 30, 2022 | 02:00 PM
Please join us in the Lecture Hall B (B.004), Arnimallee 22, or via https://fu-berlin.webex.com/meet/stephan.block