Randy Longman, Ph.D.
The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York USA
“Microbial Regulation of Mucosal Immunity in Inflammatory Bowel Disease”
- Date: Monday March 29, 2021 at 5:15 p.m.
- Zoom: Please klick the link: https://laborberlin.zoom.us/meeting/register/tJwlcOCgpzsoG9yAfPEGmppBRYdAgsyk2V2x
- and register. After registration you will receive a confirmation email with information about attending the meeting (the link will be active from 4:30 on and the seminar starts at 5:15 pm)
- Host: Christoph Klose, Institute of Microbiology, Infectious Diseases and Immunology
Here is a short excerpt about Randy's research:
One part of our lab focuses on understanding the cellular and molecular mechanisms of homeostatic inhibition/induction by microbes within the intestine. One type of mononuclear phagocyte (MNP) in the intestine which expresses the fractalkine receptor CX3CR1 plays a critical role in this process. We, and others, have shown that in the steady state, commensal microbiota support the tolerogenic function of these cells within the intestine.
However, under conditions of stress and altered microbiota that occur in IBD, these CX3CR1+MNPs can traffic luminal microbes to the mesenteric lymph nodes and stimulate aberrant responses to commensals. Under conditions of colitis, these MNPs expand in the lamina propria and, we have recently shown, support a critical function of innate lymphoid cells (called ILC3s) to produce the cytokine IL-22 and promote mucosal healing.
A second part of the lab focuses on microbial changes associated with extra-intestinal manifestations (EIMs) of IBD and their influence on mucosal and systemic immunity. In particular, seronegative spondyloarthropathies (SpA) designate a group of diseases with overlapping genetic and clinical features in which the gut is the putative port of entry for microbial triggers of systemic cellular inflammation resulting in joint disease. Thus, studying patients with IBD-associated SpA gives us a unique opportunity to understand the process by which luminal microbes shape systemic immune repertoires. (Kumar et al., J Gastroenterol., 2020; Castellanos et al., Immunity, 2018)
For more information about Randy´s research, please check www.longmanlab.org
Time & Location
Mar 29, 2021 | 05:15 PM s.t.