Elia Tait Wojno, Ph.D.
Assistant Professor, Department of Immunology, University of Washington, Seattle USA
“Prostaglandin regulation of type 2 inflammation at mucosal barriers”
- Date: Monday May 10, 2021 at 5:15 p.m.
- Zoom: Please click the link:https://laborberlin.zoom.us/meeting/register/tJIqfuqhrTIqEtfm6K1jGG2hU359tJ9q3r4u and register. After registration you will receive a confirmation email with information about attending the meeting (the link will be active from 4:30 on and the seminar starts at 5:15 pm)
- Host: Claudia Dürr, Institute of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin
Elia is very interested in meeting trainees and PIs after the talk. Please get back to Dr. Linn Lundvall (email@example.com) if you want to meet Elia.
About Elia´s research (https://www.immunology.washington.edu/faculty/primary-joint-faculty/taitwojno/):
Research in the Tait Wojno laboratory studies how immune responses and inflammation are regulated during helminth infection and allergic disease. Intestinal helminth parasite infection and allergic disease affect billions of humans worldwide, causing significant morbidity. Following helminth infection, mammals mount a Type 2 inflammatory response that is host-protective and helps to expel parasites and repair parasite-induced tissue damage.
Allergic disease features a similar Type 2 immune response that causes pathological inflammation in response to environmental allergens. Type 2 inflammation is characterized by activation of innate immune cells, including basophils and innate lymphoid cells, the polarization of CD4+ T cells to the T helper Type 2 (Th2) fate, and production of Type 2 cytokines. These immune cell activities direct changes to epithelial cell function that result in increased mucus secretion and epithelial cell turnover, leading to worm expulsion during helminth infection or pathological inflammation during allergy.
Ongoing studies in the laboratory aim to dissect cellular and molecular pathways that control the innate, adaptive, and epithelial network that orchestrates the Type 2 immune response. Current projects investigate: 1) the role of cytokines and prostaglandin lipids in innate and adaptive (T cell)-driven inflammation in the intestine and lung during helminth infection and allergy, 2) how the Notch signaling pathway regulates basophil gene regulation and function in the helminth-infected intestine, and 3) how helminth, bacterial, and viral infection and regulation of gene transcription shape immunity to infection.
Time & Location
May 10, 2021 | 05:15 PM s.t.